I imagine the use of U-500 (as opposed to U-100) is more common than I imagine it is, although I’ve only ever spoken to one person who was using it. At the time I’d never heard of it and had to go and look it up!
Insulin U-500 in severe insulin resistance in type 2 diabetes mellitus. [Review] [25 refs]
Crasto W. Jarvis J. Hackett E. Nayyar V. McNally PG. Davies MJ. Lawrence IG.
Postgraduate Medical Journal. 85(1002):219-22, 2009 Apr.
[Journal Article. Review]
AB Some patients with type 2 diabetes mellitus (T2DM) are profoundly insulin resistant and require large insulin doses to achieve optimal glycaemic control. However, large volumes of subcutaneous conventional U-100 insulin can cause discomfort at the injection site, resulting in poor concordance with insulin therapy. One therapeutic option is the use of U-500 insulin, thus reducing the insulin volume by 80%. This review will address the practical issues associated with the use of U-500, clinical efficacy and safety aspects of this concentrated insulin, which has an important role in a subgroup of patients with T2DM. [References: 25]